The Horned Frogs (30-25) will likely need to win out in Oklahoma City to reach the NCAA Tournament.
Zach Humphries and Johnny Rizer also homered in the fourth inning, when TCU set the tournament mark for runs scored in a single frame. The Sooners threw over 70 pitches in the fourth, and 11 of the 18 Horned Frogs who batted got hits.
Nathan Wiles (8-4) took the loss for the Sooners (33-23).
Wiles was tagged for nine earned runs in 3 1/3 innings.
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